ARA-290
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Compound Class: Tissue-Protective Peptide / Innate Repair Receptor (IRR) Agonist
OVERVIEW
ARA-290, also known as cibinetide, is a synthetic 11–amino acid peptide derived from the tissue-protective region of erythropoietin (EPO).
It is specifically engineered to retain EPO’s cytoprotective and regenerative signaling properties while eliminating erythropoietic activity, meaning it does not stimulate red blood cell production.
This selective design allows ARA-290 to activate cellular repair pathways without the hematological and cardiovascular risks associated with traditional EPO-based therapies.
MECHANISM OF ACTION
ARA-290 exerts its effects through selective activation of the Innate Repair Receptor (IRR), a heteromeric complex composed of the erythropoietin receptor (EPOR) and the β-common receptor (CD131). This receptor is upregulated in response to cellular stress, inflammation, or tissue injury.
Upon binding to the IRR, ARA-290 initiates multiple downstream signaling pathways involved in cellular protection and repair, including:
Anti-inflammatory signaling: Downregulation of pro-inflammatory cytokines such as TNF-α and IL-6, with increased anti-inflammatory mediators
Anti-apoptotic effects: Activation of PI3K/Akt and related pathways to reduce programmed cell death and support cellular survival
Neuroprotective activity: Modulation of neural inflammation and support of nerve fiber regeneration
Microvascular protection: Stabilization of endothelial function and reduction of oxidative stress in damaged tissues
Additionally, ARA-290 has been shown to influence nociceptive pathways, contributing to reduced neuropathic pain through both anti-inflammatory and direct neural mechanisms.
RESERCH BENEFITS
Neuropathic pain and small fiber neuropathy
Neuroinflammation and neurodegenerative pathways
Tissue and nerve regeneration
Microvascular and endothelial dysfunction
Chronic inflammatory conditions
Preclinical and early clinical studies suggest improvements in nerve fiber density, inflammatory markers, and tissue recovery processes, though further large-scale trials are ongoing.
STORAGE:
To maintain product stability and quality:
Store the lyophilized peptide at -20°C for long-term storage.
Short-term storage may be maintained at 2–8°C (refrigerated).
Keep the vial dry, sealed, and protected from light.
Avoid repeated freeze–thaw cycles, as this may reduce peptide stability.
Once reconstituted, solutions should be stored refrigerated and used within a short timeframe according to laboratory protocols.
For Research Use Only
Not intended for human consumption, medical, or veterinary use.